matlab-based toolbox for quantitative sound quality analysis Search Results


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(A) Mean squared displacement (<MSD>) of PS-PEG NP in mouse brain slices that were incubated in infusate solutions with varying osmolality. Over 100 NP were tracked per sample (N = 4 mouse brain tissues). *p < 0.05 denotes statistically significant differences. (B) Representative slices depicting the coronal plane within the mouse striatum where PS-PEG (red) and PS-COOH (green) NP were infused via CED. Yellow represents overlay of NP. Scale bar = 1 mm. (C) Vd of PS-PEG and PS-COOH determined using image-based <t>MATLAB</t> quantification methods. *p < 0.05 denotes statistically significant differences.
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matlab-based quantitative histological analysis tool  (MathWorks Inc)
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MathWorks Inc matlab-based quantitative histological analysis tool
(A) Mean squared displacement (<MSD>) of PS-PEG NP in mouse brain slices that were incubated in infusate solutions with varying osmolality. Over 100 NP were tracked per sample (N = 4 mouse brain tissues). *p < 0.05 denotes statistically significant differences. (B) Representative slices depicting the coronal plane within the mouse striatum where PS-PEG (red) and PS-COOH (green) NP were infused via CED. Yellow represents overlay of NP. Scale bar = 1 mm. (C) Vd of PS-PEG and PS-COOH determined using image-based <t>MATLAB</t> quantification methods. *p < 0.05 denotes statistically significant differences.
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Image Search Results


(A) Mean squared displacement (<MSD>) of PS-PEG NP in mouse brain slices that were incubated in infusate solutions with varying osmolality. Over 100 NP were tracked per sample (N = 4 mouse brain tissues). *p < 0.05 denotes statistically significant differences. (B) Representative slices depicting the coronal plane within the mouse striatum where PS-PEG (red) and PS-COOH (green) NP were infused via CED. Yellow represents overlay of NP. Scale bar = 1 mm. (C) Vd of PS-PEG and PS-COOH determined using image-based MATLAB quantification methods. *p < 0.05 denotes statistically significant differences.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Article Title: Strategies to Enhance the Distribution of Nanotherapeutics in the Brain

doi: 10.1016/j.jconrel.2017.07.028

Figure Lengend Snippet: (A) Mean squared displacement () of PS-PEG NP in mouse brain slices that were incubated in infusate solutions with varying osmolality. Over 100 NP were tracked per sample (N = 4 mouse brain tissues). *p < 0.05 denotes statistically significant differences. (B) Representative slices depicting the coronal plane within the mouse striatum where PS-PEG (red) and PS-COOH (green) NP were infused via CED. Yellow represents overlay of NP. Scale bar = 1 mm. (C) Vd of PS-PEG and PS-COOH determined using image-based MATLAB quantification methods. *p < 0.05 denotes statistically significant differences.

Article Snippet: Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification.

Techniques: Incubation

PS-PEG (red) and PS-COOH (green) NP distribution in the striatum 1 hour post-administration vi a CED. White bold-arrow indicates direction of infusion. NP near the striate arteries were imaged following CED in (B) water, (C) 0.9% saline or (D) 3% saline. Blue represents cell nuclei (DAPI). Overlay of NP is represented as yellow. Relative distribution of NP fluorescence in PVS away from the striate artery following CED in (E) water, (F) 0.9% saline or (G) 3% saline. At least N = 3 striate vessels were quantified for each condition. (H) Percent coverage of NP fluorescence within the ICS calculated using image-based MATLAB quantification. Statistically significant differences are denoted by *p < 0.05.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Article Title: Strategies to Enhance the Distribution of Nanotherapeutics in the Brain

doi: 10.1016/j.jconrel.2017.07.028

Figure Lengend Snippet: PS-PEG (red) and PS-COOH (green) NP distribution in the striatum 1 hour post-administration vi a CED. White bold-arrow indicates direction of infusion. NP near the striate arteries were imaged following CED in (B) water, (C) 0.9% saline or (D) 3% saline. Blue represents cell nuclei (DAPI). Overlay of NP is represented as yellow. Relative distribution of NP fluorescence in PVS away from the striate artery following CED in (E) water, (F) 0.9% saline or (G) 3% saline. At least N = 3 striate vessels were quantified for each condition. (H) Percent coverage of NP fluorescence within the ICS calculated using image-based MATLAB quantification. Statistically significant differences are denoted by *p < 0.05.

Article Snippet: Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification.

Techniques: Saline, Fluorescence

Representative coronal images of PLGA-PEG (red) and PLGA (green) NP infused in (A) 0.9% saline and (B) 3% saline. Data represent the average of N ≥ 3 mouse brain specimen for each condition. (C) Quantified Vd of PLGA-PEG and PLGA NP in mouse striatum. Inset depicts the amplified view of PLGA Vd. *p < 0.05 denotes statistical significant difference. High magnification images of PLGA-PEG NP near lateral striate arteries following infusion in (D) 0.9% saline and (E) 3% saline. Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification. Statistical significant difference is denoted by *p < 0.05.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Article Title: Strategies to Enhance the Distribution of Nanotherapeutics in the Brain

doi: 10.1016/j.jconrel.2017.07.028

Figure Lengend Snippet: Representative coronal images of PLGA-PEG (red) and PLGA (green) NP infused in (A) 0.9% saline and (B) 3% saline. Data represent the average of N ≥ 3 mouse brain specimen for each condition. (C) Quantified Vd of PLGA-PEG and PLGA NP in mouse striatum. Inset depicts the amplified view of PLGA Vd. *p < 0.05 denotes statistical significant difference. High magnification images of PLGA-PEG NP near lateral striate arteries following infusion in (D) 0.9% saline and (E) 3% saline. Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification. Statistical significant difference is denoted by *p < 0.05.

Article Snippet: Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification.

Techniques: Saline, Amplification, Fluorescence